- chriskiehl/Gooey: Turn (almost) any Python command line program into a full GUI application with one line
General recommendation can be found on Command-line Applications - The Hitchhiker's Guide to Python.
- Clint: Python Command-line Application Tools. Provides many useful utilities such as coloring, indenting, etc.
- Click: argparse replacement, focusing building complicated application
- google/python-fire: Python Fire is a library for automatically generating command line interfaces (CLIs) from absolutely any Python object.